FGBI "ARRIAH" has developed a vaccine against clinical and subclinical mastitis of cows "Mastivak-EVA"

In the process of searching for vaccine strains, diagnostic work was carried out to study biological material from cows in the amount of more than four hundred samples, while the frequency of pathogen isolation was 75%.

The main role in the etiology of cow mastitis in the Russian Federation is occupied by: Staphylococcus aureus, Escherichia col, Streptococcus agalactiae, Streptococcus dysgalactiae and Streptococcus uberis.

During bacteriological examination of milk samples, 56% of pathogens were isolated from cows with subclinical mastitis, 44% were clinical manifestations of the disease.

All isolated microorganisms were comprehensively studied, and 8 “vaccine candidates” were selected from them. The antigenic composition of the immunobiological preparation consists of inactivated bacterial cells of Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis, two strains of Staphylococcus aureus, Staphylococcus hyicus and two strains of Escherichia coli.

The vaccine has passed all the stages of preclinical, laboratory vivarium, tests to determine the safety and efficacy.

To date, at the final stage, the drug is being tested in the field on target animals, and a set of documents for the registration dossier is being actively prepared, which in the second half of 2023 will be transferred to the All-Russian State Center for the Quality and Standardization of Medicines for Animals and Feed, subordinated to Rosselkhoznadzor ( FGBU "VGNKI") for the registration procedure.

Since the beginning of the year, ARRIAH scientists have registered two vaccines - for the prevention of mycoplasmosis in poultry farming "ARRIAH-Bimivak" and for the prevention of viral diseases in dogs "Karnikan-4".

In total, the Federal Center for Animal Health plans to register 10 new vaccines in 2023. Specialists are working on immunobiological preparations for birds. These include the Newcastle disease live dry vaccine (for broilers) and the H9 avian influenza and Newcastle disease vaccine (Multi). A drug is also being prepared for diseases of salmon fish.

In addition, FGBI ARRIAH has developed an inactivated vaccine against porcine reproductive and respiratory syndrome.