US develops new method to fight PRRS

During the study , the scientists applied a number of innovative methods to identify small molecules that can interfere with the interaction of the PRRSV with the target receptor in pig cells (CD163). They argue that this approach allows you to block the development of infection at an early stage.

Initially, the researchers were able to isolate one small molecule with the desired properties. Then, using algorithms developed by Atomwise, they were able to identify 96 other compounds that have similar chemical structures. Among them, three more small molecules were found that can block the effect of the PRRS virus on CD163. 

The scientists say they have confirmed a consistent result in a laboratory model that represents a new approach to preventing PRRS infection in pigs. They believe that this method is a good alternative to vaccines under development, which do not provide adequate protection and are extremely expensive to manufacture. In addition, the constantly mutating virus requires continuous work on new vaccine options, which also seems to be a difficult task that requires large financial costs.

According to scientists, small molecules have a number of advantages. They are simple and inexpensive to manufacture, store and use. They simply need to be added to feed for mass immunization of livestock, instead of individually vaccinating thousands of piglets, the publication notes. In the near future, it is planned to test all four molecules on animals to identify side effects, as well as to determine the most optimal prophylactic dose.

PRRS causes significant damage to swine farms worldwide every year. In the US , farmers lose about $664 million a year. In Europe, annual losses average 1.5 billion euros.