The Federal State Budgetary Institution "VGNKI" has developed a method for determining the mass fraction of quinolones in livestock products

Photo is illustrative in nature. From open sources.

Adds

The goal of this work was to optimize chromatographic conditions and mass spectrometric detection parameters, as well as methods for preparing samples for analysis.

Today, this technique makes it possible to determine the desired compounds in the concentration range from 1 to 1000 μg/kg for quinolones and from 1 to 2000 μg/kg for difloxacin and flumequin in by-products. In addition, the list of analyzed substances was expanded to emergent (relatively recently appeared) analytes, such as nadifloxacin, gatifloxacin, cinoxacin, sparfloxacin , orbifloxacin, fleroxacin, gemifloxacin, pazufloxacin, enoxacin , grepafloxacin, which in the future will make it possible to quickly monitor the presence of drugs in livestock products based on connection data.

Quinolones, especially fluorinated ones, are one of the most important broad-spectrum antibacterial drugs in veterinary medicine. Most often, quinolones are used to treat diseases of the urinary, respiratory and digestive systems of farm animals (cattle, small livestock, poultry and others) caused by pathogenic microbes.

Inappropriate use of antibiotics for the prevention and treatment of diseases of farm animals, as a rule, leads to their contamination of livestock products, which, in turn, can have a negative impact on human health . Among such influences, one can highlight skin allergic phenomena, imbalance of intestinal microbiota, arthrotoxic effects, and increased resistance of pathogenic microorganisms to the drugs used.

It is precisely because of the risk of resistance to antimicrobial drugs, as well as a large number of side effects from their use in Russia and other countries, that regulatory restrictions on the content of various fluoroquinolones and quinolones have been introduced on the territory of the Russian Federation, and maximum permissible levels (MAL) of residues have been established. of these antibiotics in food.

As a result of the research, methodological guidelines were developed and metrological certification of the methodology was carried out. In 2024, the methodology will be included in the scope of accreditation and introduced into the activities of the Testing Center of the Federal State Budgetary Institution "VGNKI".

Tags:

антибиотиков, здоровье, циноксацин, эноксацин

Read together with it:

Innovations in broiler feeding: savings and bird health
The use of antibiotics in poultry farming remains a pressing issue. Long-term use of these drugs leads to the development of resistance in pathogenic bacteria and negatively impacts beneficial intestinal microflora, weakening the birds' immune system . Research shows that adding probiotics, zeolite, and inulin to broiler diets can effectively replace antibiotics . Probiotics restore normal intesti...
EU and Mercosur: Experts warn of shortage of EU veterinarians to control imports and associated health risks
The agreement between the European Union ( EU ) and Mercosur, which is currently stalled, has caused concern in the primary sector of various EU countries, including Spain, where, in addition to livestock breeders and agricultural producers, veterinarians have joined the complaints. It should therefore be remembered that various veterinary institutions, such as the colleges of Asturias, Lugo and C...
The Master of Steam: The Story of a Businessman Who Left a Successful Printing Business to Become a Spa Master
The story of Alexey Kozhukhovsky, a resident of the agro-town of Khatezhino in the Minsk region, is inspiring proof that a true calling can be found at any age, and that a drastic career change can be a major achievement. When Alexey realized that money was no longer his primary motivation, he decided to leave the printing business to which he had dedicated two decades. He was drawn to creation, n...
Doctors reported which treatment errors the new flu standard has highlighted.
Recommendations against the use of antibiotics to treat influenza have long been in place. The new standard has highlighted these errors once again, doctors interviewed by RBC said.The new standard for flu treatment has highlighted the main mistakes made in treating and self-treating the flu, doctors interviewed by RBC reported. The exclusion of antibiotics and diuretics from the list of non-drug ...
Quiet dismissal: how it manifests itself and how to correct the situation
An employee remaining silent at meetings or offering nothing is just a small part of the symptoms of a quiet resignation. BITOBE asked HR expert Alexandra Koroleva what other red flags there are, what are the potential business implications, and whether changes can be made.This material is part of RBC's new Education section , where we discuss how to develop skills, make informed decisions, and ad...
From Tractor Driver to Businessman: The Story of a Belarusian Who Built a Farm from Scratch and a Church in a Village
Vasily Matskevich News Topics Vasily Matskevich is a well-known figure in the Dokshitsy district. His fellow villagers unanimously call him a "Master" with a capital "B." He has good reason to be: our hero built a strong farm from scratch, built a church in his native village, raised five children, and never refuses to help those in need. 7 Days correspondents learned how this tractor driver manag...
Genomic selection in livestock farming in Stavropol: support and new prospects
Genomic selection is based on the use of genetic information to identify and select animals with the best traits. It can be used to predict the productivity of cows even before they are born, allowing farmers to optimize their herds and improve the quality of meat and milk. In support of this technology, Stavropol Krai authorities are offering financial assistance for genomic evaluation. The regio...
Europe's first outbreak of bird flu among cows has sparked alarm in Galicia.
Официальное подтверждение первого случая птичьего гриппа у крупного рогатого скота на территории Европы вызвало тревогу в системах здравоохранения и представляет собой особенно серьезную потенциальную опасность для Галисии, учитывая зависимость сельских районов страны от молочного сектора. Министерство сельского хозяйства Нидерландов сообщило об обнаружении антител к вирусу H5N1 у молочной коровы ...
Канада одобрила использование свиней, устойчивых к PRRS, в пищевой цепочке
Вирус синдрома репродуктивных и респираторных заболеваний свиней (PRRS) — одно из самых разрушительных заболеваний, поражающих сельскохозяйственных свиней, приводящее к значительным убыткам для канадских производителей и повышению цен для потребителей. Инфекция PRRS может вызывать у свиней тяжелые симптомы, включая проблемы с дыханием, лихорадку, неспособность к приему пищи, мертворождение и гибел...