FSBI "VGNKI" is developing a methodology for identifying the content of an extended list of NSAIDs in livestock products

As part of the research, the specialists of the Federal State Budgetary Institution VGNKI are working on the creation of a sensitive method for determining the content of an extended list of non-steroidal anti-inflammatory drugs (NSAIDs) in livestock products using high-performance liquid chromatography with mass spectrometric detection, based on a new approach to sample preparation.

NSAIDs are a group of drugs that have a pronounced analgesic, antipyretic and anti-inflammatory effect. NVPS have long been used in everyday veterinary practice and have proven to be a reliable tool for combating various animal diseases. Medicines accelerate the process of recovery of sick animals, relieve pain, restore blood vessels, normalize metabolism and oxygen metabolism in affected tissues, and reduce body temperature.

However, if the timing of the removal of these drugs from the body of animals is not observed, their residual amounts can be found in products of animal origin. The ingestion of NSAIDs into the human body can lead to damage to the gastrointestinal mucosa and liver, impaired filtering ability of the kidneys, thrombosis and internal bleeding.

And although in the territory of the Customs Union, according to TR TS 021/2011, the content of NSAIDs in food products is not allowed, the number of positive samples detected in livestock products is increasing every year. In addition, new compounds of the NSAID group have recently been synthesized. Therefore, the existing GOST 32881-2014 needs to be improved in the form of an extension to these connections. However, today, when conducting monitoring studies of livestock products, it is more expedient to apply the QuEChERS principle (“quickly, easily, cheaply, efficiently, reliably and safely”), based on dispersive solid-phase purification of extracts.

The methodology developed at VGNKI will be used as part of the state monitoring of the safety of products of animal origin, in order to protect the HEALTH and well-being of the population, and will also provide reliable control over these compounds when exporting products to the EU and CHINA.