
Scientists from Washington University in St. Louis have discovered an antibody that can neutralize various variants of the coronavirus. The results of the study were published in the journal Immunity, and are also available on the website of the educational institution.
The researchers injected mice with a receptor-binding domain, a protein fragment located on the spiny processes of the “crown”. They then isolated the antibody-producing cells, generating 43 neutralizing proteins. During experiments in a Petri dish, scientists studied the ability of these antibodies to fight the SARS-CoV-2 virus.
Nine of them, which did the best job, were reintroduced to rodents. Two neutralizing proteins were found to be most effective against SARS-CoV-2. Their scientists tested against all major strains of SARS-CoV-2 (alpha, beta, gamma, delta, kappa and iota), as well as other potentially dangerous variants. Ultimately, one antibody, SARS2-38, was able to neutralize all strains.
Scientists announced a drop in the effectiveness of vaccines in the conditions of the delta strain Society
In addition, scientists have identified SARS-CoV-2 mutations that can prevent the SARS2-38 antibody from fighting the virus. However, these mutations occur only in 0.04% of cases.